- Rose Marie Luttmer
- Rose Marie Platt
- Rose Turford and Carolyn Stevens
- Rosemary Altea
- Rosemary Hom
- Roswell Crash
- Route 29 Stalker
- Roxann and Kristopher Jeeves
- Roy Caffey
- Rudolf Diesel
- Rudolf Hess
- Rufino Castaneda
- Russell Evans
- Russell Turcotte
- Russell and Shirley Dermond
- Ryan Stallings
- Sabrina Aisenberg
- Sacramento Thrill Killer
- Sagebrush Rebellion
- Sal Guardado
- Sally Stone
- Salvatore Caruana
- Salvatore Spinnato
- Sam Wodke
- Sam Zelikson
- Samantha Kibalo
- Sami Eisbart
- Sammy Wheeler
- Samuel Glover and Marshall Kirkpatrick
- San Pedro Mummy
- Sandra Evans
- Sandra Flynn Fisher
- Sandra Nevarez
- Sandra Orellana
- Sandra Valade
- Sandy Breed and Bruce Clark
- Sandy Cleaver
- Santos Family
- Sarah DiGennaro
- Sarah Powell
- Sarah Pryor
- Savanna Todd
- Savior of Cathy Loving
- Savior of James Vernon
- Savior of Phillip Macri
- Savior of Renee Wilson
- Savior of Samantha Roberts
- Savior of Steve Newton
- Savior of Wendy Radcliffe
- Savior of Wilma Drew
- Saviors of Colleen Frangione
- Saviors of Doris Smith
- Saviors of Duane Miller
- Saviors of Michele West
- Saviors of the Dover Family
- Scott Enyart
- Scott Hill
- Scott Johnson
- Season 1
- Season 10
- Season 11
- Season 12
- Season 13
- Season 14
- Season 15
- Season 16
- Season 2
- Season 3
- Season 4
- Season 5
- Season 6
- Season 7
- Season 8
- Season 9
- Seattle Arsonist
- Selena Edon
- Sensing Murder
- Sergio Farina
- Series Templates
- Seth Arathorne
- Seth Floyd
- Shadow
- Shafaa Salem
- Shane Stewart and Sally McNelly
- Shane Walker
- Shannon Sites
- Shannon Smith
- Shannon Verhage
- Sharon Eugenia Davis
- Sharon Johnson
- Sharon Kinne
- Sharon Rogers
- Shauna Maynard
- Sheldon Weinberg
- Shelly Malone
- Sherri Holland
- Sherry Eyerly
- Sherry Hart
- Sherry Lynn Marler
- Shirley Finn
- Shopping Bag Bandits
- Shorts Robber
- Shotgun Bandit
- Shotgun Jane Doe
- Sidney J. Reso
- Skeleton Canyon Treasure
- Smith Home
- Snapped
- Sodder Family
- Solved on ID
- Solway Firth Spaceman
- Son of Sam
- Sonny Liston
- Sonya Fitzpatrick
- Southern California Robber
- Spike's Unsolved Mysteries Series List
- St. James Hotel
- Stahl Painting Theft
- Stallings Family
- Stan Milford and Jon Dover
- Stanley Gryziec
- Stanley Obas
- Stanton Bones
- Star Palumbo
- Stefanie Stroh
- Stephanie Booker
- Stephen Anderson
- Stephen Harkins and Ruth Cooper
- Steve Hadley
- Steve Sandlin
- Steve Shores
- Steve Wilson
- Steven Cox
- Steven Oliver
- Stockton Arsonist
- Stryder Styarfyr
- Stuart Heaton
- Su-Ya Kim
- Su Taraskiewicz
- Sugar
- Suggestions
- Sumter County Does
- Superbike Motorsports Murders
- Susan Bachman
- Susan Cappel
- Susan Harrison
- Susan Jacobson
- Susan King
- Susan Roberts
- Susan Walsh
- Susan Zaharias
- Susan and Shane Hamwi
- Suzanne Davis
- Sweetheart Swindler
- Sylvan Lazarus, Carl Cobb and Bernard Brady
- T. J. Ainsworth
- TWA Flight 800
- Tabitha Tuders
- Tallman House
- Tammy Lynn Leppert
- Tammy Mahoney
- Tammy Williams
- Tammy and Diego Flores
- Tampa Bay Robber
- Tandem Bandits
- Tanya Palmer
- Tanya Smith
- Tara Baker
- Tara Breckenridge
- Tara Calico
- Tara Grinstead
- Tatum House
- Taylor Kramer
- Ted Binion
- Ted Bundy
- Ted Loseff
- Televangelist Bomber
- Teresa McDonald
- Teresita Basa
- Terri McClure
- Terry Lee Conner and Joseph Dougherty
- Terry Lucas
- Terry Smith
- Terry Sullivan
- Teryn Hedlund
- The Allagash Abductions
- The Baddaduk
- The Bald Mountain Shooters
- The Bird Road Rapist
- The Black Dahlia
- The Boy In the Box
- The Brother of Sylvia Wemhoff
- The Child of Mac McDonald
- The Children of Doreen Espinosa
- The Children of Faith Brown
- The Children of Georgia Tann
- The Children of Hilda Craun
- The Children of Uta Collins
- The Comedy Store
- The Countess
- The Crew of the Casie Nicole
- The Crew of the Freedon
- The Crew of the L-8
- The Crew of the Liebling
- The Crew of the Sarah Joe
- The Curse of King Tut
- The Daughter of Gerda Burian
- The Daughter of Lavar Bates
- The Daughter of Oscar Norton
- The Devil's Backbone
- The FBI Files
- The Families of the S.S. Muskogee Crew
- The Family of Charles Stubin
- The Family of Dolores Camarena
- The Family of Dolores Valadez
- The Family of Georgia Boyd
- The Family of Jeanne Martin
- The Family of Joe Soll
- The Family of LaDonna Alfano
- The Family of Monica Libao
- The Family of Pat Mealbach
- The Family of Tammy Makram
- The Family of Terris Christie Derby
- The Family of Victor Simon
- The Father of Elizabeth Bersanetti
- The Father of Janet O'Regan
- The Father of Jeannie Wagner
- The Father of Kathleen Belcher
- The Fatima Miracle
- The Friend of Moises Treves
- The Friend of Russell and Jean Johnson
- The Friend of Stephan Ross
- The Friend of Tom Vaughn
- The Friends of Fritz Vincken
- The General Wayne Inn
- The Hatbox Baby
- The Hunt with John Walsh
- The Ice Man
- The Kazakhstan UFO
- The Mona Lisa
- The Mother of Barbara Smith and Barbara Ratner
- The Mother of Carla Downing
- The Mother of Margaret Smith
- The Mother of Tim Harrell
- The Nanny of Jackie Cooper
- The New Detectives
- The Parents of Brenda Abbey
- The Parents of Elizabeth Bagwell
- The Parents of Gale Samuels
- The Parents of Jeannie Frazier
- The Parents of Jeri Graves
- The Parents of Kimberly Smith
- The Parents of Miriam
- The Queen Mary
- The Search of Alexandra Stantzos
- The Search of Bob Coleman
- The Search of Helen Elas Conka
- The Shroud Of Turin
- The Siblings of Aleatha Evertz
- The Siblings of Debbie Hamilton
- The Siblings of Eugene Price
- The Siblings of Jeff Linn
- The Siblings of Jim Boumgarden
- The Siblings of LeeAnn Robinson
- The Siblings of Martha Smith
- The Siblings of Tina Shiets
- The Signal Mountain Murders
- The Sister of Charlene Long
- The Sister of Lois Cappoziello
- The Sisters of Jackie Dragon
- The Skunk Ape
- The Smoker Car Baby
- The Son of Bobbi Page Myler
- The Son of Margaret Leoni
- The Sons of Jim Fontes
- The Springfield Three
- The Unabomber
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