Unsolved Mysteries Wiki

Real Name: Mario Alberto Lozano
Aliases: None known
Wanted For: Murder
Missing Since: 2004

Isaac Guzman


Details: Mario Lozano is wanted for the murder of Isaac Guzman, which occurred in Watsonville, California on December 3, 2004. Isaac was a seventeen-year-old high school senior who had hopes of becoming a construction worker like his father. Isaac was very close to his cousin Roxanne; the two considered themselves brother and sister. At the time, Lozano and Roxanne were dating and living together. When Isaac heard rumors that Lozano was abusing Roxanne, he confronted him. Things remained tense between the two as a result.
At 3PM on December 3, Isaac left school and went to a market across the street on Airport Boulevard to wait for his father to pick him up. Lozano was apparently waiting for him to leave school. He confronted Isaac and the two got into another argument. When Isaac tried to defend himself, Lozano pulled out a knife and stabbed him multiple times. Tragically, he passed away at a nearby hospital. Lozano fled the scene and was later charged with murder.
Since his disappearance, Lozano has been spotted in Mexico, Arizona, Idaho, and California. There is a $20,000 reward available in this case.
Extra Notes: The case was uploaded to the Unsolved Mysteries website on January 15, 2016. The person interviewed in the video is murder victim Isaac Guzman's aunt Sally. Lozano was profiled on both America’s Most Wanted and The Hunt with John Walsh.
Results: Captured. In February of 2018, Lozano was arrested in Mexico thanks to tips from social media. In August, he was extradited back to California to face murder charges.